Pediatr Blood Cancer 2014;61:1329–1335 MEETING REPORT Updates on Histiocytic Disorders
نویسندگان
چکیده
Histiocytoses describe a diverse group of proliferative disorders involving dentritic cells and macrophages. They include a spectrum of diseases including a reactive inflammatory accumulation of cells, pathologic immune activation, or neoplastic clonal proliferation. Advanced molecular technologies are resulting in new breakthroughs in understanding the pathophysiology of histiocytic disorders that are changing the field. The purpose of this update report is to aid in understanding the subtle differences in pathogenesis of three most common histiocytic disorders— Langerhans cell histiocytosis (LCH), hemophagocytic lymphohistiocytosis (HLH), and Rosai Dorfman disease (RDD) and how new insights lead to the hope for novel therapeutics (Table I).
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